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Saturday, November 08, 2014

UCP2 Interactome As Targets For Novel Anti-Diabetic Drugs

Today we are featuring "UCP2 Interactome As Targets For Novel Anti-Diabetic Drugs" by Musanabaganwa et al. in the Rwanda Medical Journal vol.70 no.4.

The purpose of this study was to assess the role of mitochondrial dysfunction in the onset and progression of diabetes to identify the proteins that interact with UCP2 and evaluate their suitability for novel anti-diabetic drugs. 

The proteins were detected using the STRING 9.0 database. The proteins identified for the use of anti-diabetic drugs were leptin (LEP), peroxisome proliferator-activated receptor gamma (PPARG), ghrelin/obestatinprepropeptide (GHRL), as well as many others. 

In addition to the identification of proteins, the E values associated were also identified using STRING 9.0. The predicted interactions are supported by the use of such methods as text mining, occurrence, neighbourhood, database, fusion, experimental, and co-expression data. 

To this end, development of lead compounds against these targets will help to address the burden of diabetes and help to provide effective and safer anti-diabetes medications in the near future. 

For this article and others from this issue, click here.

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